The upgrade went pretty smoothly but I had to re-install my ATI drivers.
Problem I had was that after the upgrade Lotus Notes 8.5.1 no longer worked!
In order to get a better understanding of what may be happening I opened a terminal and typed:
This indicated that there was a missing library - libesd0
To get Lotus Notes working again, all I did was
sudo getlibs -p libesd0
And it worked again.
Since I did an upgrade my assumption is therefore that my previous post about getting Lotus Notes working on karmic x64 will still work with this single addition.
I tried this on a brand new KVM/QEMU virtualised machine running ubuntu 10.04 x64 and found that those instructions together with the fix above will give you a running Notes 8.5.1 on lucid x64